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There is no current evidence to suggest that GLP-1 medications cause hypothyroidism

It concluded: "There is a strong indication that GLP-1 receptor agonists may have a useful role in future treatment of Parkinson's disease." Of note, both trials had a washout period after the drug treatment ended and the benefit for motor symptoms persisted

Bottom Line GLP-1 drugs are not currently FDA-approved for people who dont have obesity or diabetes, but clinicians increasingly recognize the benefits of losing 10 to 30 pounds with GLP-1 therapy

Now, many GLP-1 drugs are approved for obesity

Furthermore, pancreatic ductal adenocarcinoma and pancreatic intraepithelial neoplasia, both associated with pancreatic cancer development, express GLP-1R, while normal pancreatic ductal cells and acini demonstrate proliferative responses to GLP-1RAs, suggesting that incretin-based medications may induce specific proliferative changes in the islets

It may also trigger adaptive metabolic responses that slow weight loss over time and increase the likelihood of weight regain after treatment cessation