Alyssa Dominguez, an endocrinologist at the University of Southern Californias Keck School of Medicine
As Yuval Ramot from the Department of Dermatology at Hadassah Medical Center notes: "Almost all local reactions to subcutaneously administered biological agents can be prevented by changing the injection techniques, patient education, and training." While most redness and warmth from injections resolve within 24 to 48 hours, mistakes in technique can prolong these symptoms
Examples of GLP-1s include semaglutide (Wegovy), and liraglutide (Saxenda)
The REWIND trial, which enrolled nearly 10,000 participants, demonstrated more modest reductions in HbA 1c (0.6 to 0.7%) and weight (around 2 kg) with dulaglutide, yet still achieved a 15% reduction in microvascular complications (HR 0.85
The PlexusDx Precision Peptide Genetic Test analyzes 14 pathways, 49 peptides, 150+ genetic insights, including TCF7L2, FTO, GLP1R, and MC4R
GLP-1 modulates actin polymerization, improving insulin sensitivity and glucose-stimulated insulin secretion Chronic hyperglycemia, or glucotoxicity, causes pancreatic cell dysfunction, diminished glucose-stimulated insulin secretion, and the production of long actin stress fibers 6,7
