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doi: 10.3390/epidemiologia5030032 3

Reducing lean mass can have several negative effects on the body, including slowing metabolism, reducing strength and endurance, and increasing the risk of injury

Monitor carefully: Watch for side effects and adjust as needed

Because it is applied before bed and removed in the morning, LeanPatch fits seamlessly into a low-effort lifestyle

The most significant recent finding: a May 2026 Lancet randomized controlled trial (108 patients, 26 weeks) found semaglutide 2.4 mg reduced heavy drinking days by 41.1 percentage points versus 26.4 on placebo, a statistically significant 13.7-point difference

Several peripheral and central mechanisms are believed to be involved, including altered gut hormone secretion, decrease in energy expenditure following weight loss, and psychological processes associated with the food reward system