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Teoh PL, Mohd Akhir H, Abdul Ajak W, Hiew VV

Six RCTs reported liver function tests (AST, ALT, -GT) [13, 18, 3235], four RCTs reported lipid profile tests (HDL cholesterol, LDL cholesterol, total cholesterol, triglyceride) [13, 3234], six RCTs reported body indicators (BMI, weight, waist circumference) [17, 18, 3235], two RCTs reported inflammatory factors (hs-CRP) [16, 33], and two RCTs reported adverse events [32, 33]

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The injury resembled human PSC, and was characterized by progressive hyperplasia, luminal complexity and obstruction, epithelial injury, reactive changes and periductal inflammation

Deviate from those conditions, and the effective shelf life shrinks