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Since the data obtained from KID mice showed levels of bioactivity similar to the control group, the research team hypothesized that the difference in recorded results stemmed from the RIA kit only recording fragments of IGF-1 DES that were bound to IGF-1 binding proteins with a low affinity [3]

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Methyltransferases transfer a methyl group (CH3) from S-adenosylmethionine (SAMe) to a toxic substance or drug molecule, therefore neutralizing reactive groups, regulating metabolic pathways, and enhancing stability and excretion of toxic metabolites

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