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Pregnancy, infertility, and MTHFR: One of the first researched links to MTHFR variants was neural tube defects in infants

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Cheng B, Ding K, Chen P, Ji J, Luo T, Guo X, et al

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As present in Table 2, five ML models showed moderate performance under the Borderline-SMOTE approach, with AUC values ranging from 0.642 0.073 (DT) to 0.870 0.022 (LR), but struggled with recall, as seen in models like RF (0.099 0.073), KNN (0.124 0.048), which achieved high accuracy but low recall, indicating challenges in handling imbalanced data

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