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In our bulk RNAseq data, we noted that pathways such as oxidative phosphorylation and electron transport chain were significantly downregulated ( Supplementary Figures 5B, C )

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HMSC-E4 retained typical hMSC morphology, surface markers, and viability, but showed a 10,000-fold increase in Exendin-4 mRNA and a 20-fold rise in protein levels