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MDA level was significantly higher in the PE group than in the NP group (p=0.002)

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According to the criteria adopted in these guidelines, subjects with FH and without other major risk factors are considered high-risk patients, while those with FH and ASCVD or other major risk factors are considered very high-risk patients, which implies a recommendation to achieve specific treatment goals ( 10 years, the target LDL-C concentration should be 500 mg/dl) and an increased rate of atherosclerosis development (tendon and skin xanthomata below 10 years of age) and significantly increased cardiovascular risk [9, 265]

To remedy this, the trial ruling (in which seven defendants were sentenced to death) gave an outline of Permissible Medical Experiments. This was called the Nuremberg Code and was later expanded by the World Medical Association into the Declaration of Helsinki