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Importantly, TNF type 1 receptor knockout mice are resistant to the initiation and progression of NAFLD in response to both high-carbohydrate and methionine- and choline-deficient diets 26,27

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The potential dimer interface with the largest buried surface area was excluded from detailed analysis as the distance between the termini of each domain was too great to allow each domain to be linked by the interdomain linker peptide (86)