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11.3.3 potential risks and challenges of modulating CUL5 in cellular immunotherapies CUL5 is widely expressed in the human body (139) and participates in numerous physiological functions, including the regulation of cell proliferation and the cell cycle (50), DNA damage response and repair (102, 202), maintenance of proteostasis, and signal transduction (119)

Li et al., 2016)

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The ME3 gene is located on chromosome 11q14.2 and is composed of 22 exons that generate four alternatively spliced mRNAs that all encode the same 604 amino acid protein