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A modified SELEX approach to identify DNA aptamers with binding specificity to the major histocompatibility complex presenting ovalbumin model antigen

Sakamoto N, Kono S, Wakai K, Fukuda Y, Satomi M, Shimoyama T, et al

The device is placed under the skin on the left chest area through minor surgery performed under local anesthesia

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FOXO4-DRI a D-retro-inverso peptide made from protease-resistant D-amino acids competitively displaces endogenous FOXO4 from p53, freeing p53 to activate its apoptotic program selectively in senescent cells (Baar et al., 2017)