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(D, E, F) Cells were pretreated with 1, 10 and 100 nM GLP-1 for 1 h, and incubated with H 2 O 2 (1 mM) for 12 h, and then labeled with the fluorescent dyes Rhodamine 123, superoxide indicator DHE, and nucleic acid stain Hoechst 33342

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We also demonstrate intramolecular Friedlnder macrocyclization reactionssufficiently mild to be employed on unprotected and in vitro-translated peptidesthat embed a quinoline pharmacophore directly within the peptide backbone

The problem is the gap between preclinical data and clinical evidence