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Taking GLP-1s appears to alter these areas and change the levels of reward-related neurotransmitters dopamine and glutamate, a review of related studies suggests

For women with MCAS, layering in a low histamine diet reduces inflammatory triggers that worsen bloating, reflux, or headaches

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The first head-to-head clinical trial (SURMOUNT-5, published in the New England Journal of Medicine in 2025) showed tirzepatide produced 20.2% average weight loss at 72 weeks compared to 13.7% for semaglutide approximately 47% greater relative weight loss

The metabolic profile can normalize

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