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The FDA has not approved topiramate for weight loss but the medication is used off-label for weight management

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Evidence varies by protocol, device, and dosing

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Every FDA-approved GLP-1 receptor agonist and GIP/GLP-1 dual agonist carries the class boxed warning for thyroid C-cell tumor risk observed in rodent studies, and all are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

Antiretroviral drugs (ART): Orlistat may reduce absorption of some antiretroviral medicines