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Compared to the parent BBR, chloro and bromo BBR reduced glucose levels and cytotoxicity in HepG2 cells, with chloroberberine showing better efficacy (Ding et al., 2014)

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They are also immune-neutral, meaning they are unlikely to trigger rejection

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Built for compounded and vial-based GLP-1 prescriptions

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Firstly, the majority of studies have been conducted using in vitro cell models or animal models, with a lack of clinical investigations, particularly high-quality RCTs

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