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For patients who want to add lean tissue and reduce fat simultaneously, rather than bulk and cut in separate cycles, GH secretagogues create the hormonal environment that makes concurrent recomposition more achievable than it would be with training and nutrition alone

Currently approved and commonly used GLP-1R agonists include exenatide (the synthetic form of Ex-4, a naturally occurring GLP-1R agonist), lixisenatide, dulaglutide liraglutide and semaglutide ( Figure 2 ) (17, 110)

If you are using semaglutide and notice changes in your motivation or focus, its important to work closely with your healthcare provider to ensure the best possible outcomes

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The GLP-1 paradox exists in plain sightstop the medication, and patients regain most of the weight and complications

The medication works by mimicking a natural hormone that regulates hunger, helping to reduce cravings and increase feelings of fullness