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Research into the individual peptides suggests distinct but potentially complementary mechanisms: Retatrutide through hormonal signaling for appetite and glucose, and MOTS-c through direct mitochondrial modulation and AMPK activation
Lai Y, Hickey RW, Chen Y, Bayir H, Sullivan ML, Chu CT et al
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Ex vivo approaches, including MAPPs, PBMC proliferation assays, and ELISpot, can then experimentally investigate whether these predicted epitopes are processed and presented by human immune cells
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