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Combining it with benzodiazepines, Z-drugs, or alcohol creates additive CNS depressant effects

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Diabetologia 52 , 16801682 (2009)

Any haziness, turbidity, or cloudiness indicates protein aggregation, where peptide molecules have clumped together into particles large enough to scatter light

adults who tolerate it for at least four weeks may increase to a maximum 7.2 mg when additional weight reduction is clinically indicated