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The imidazole group of allantoic acid confers pH sensitivity, promoting rapid degradation in acidic inflammatory sites (230)
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Foster GD, Wadden TA, Makris AP, Davidson D, Sanderson RS, Allison DB, et al
Other serious side effects may occur, which include: Severe allergic reaction (symptoms such as hives, difficulty breathing, chest pain, or swelling of the face, lips, tongue, or throat require emergency medical help) Severe skin reactions (the following symptomsfever, sore throat, burning eyes, skin pain, red or purple rash, blistering or peeling skinrequire emergency medical attention) Liver damage Heart attack Severely high blood pressure Seizures Angle-closure glaucoma Who should not take Contrave Contrave is not appropriate for everyone
Also see the evidence for other ingredients promoted for osteoarthritis and our Top Pick supplements for joints in our Joint Health Supplements Review
doi: 10.1096/fj.11-196782
