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Insulin receptors are most densely concentrated in the olfactory bulb, cerebral cortex, hippocampus, hypothalamus, cerebellum, and choroid plexus (161)

meanwhile, tepotinib inhibits c-Met signaling in both HGF-dependent and independent ways [156]

Because K+ channels are required for membrane repolarization in TASR, these cells remain in a depolarized state for an extended period, resulting in prolonged bitter signaling (74)

In vitro studies demonstrate that IGF-1 significantly increases DNA synthesis and collagen I production in tenocyte cultures

This is a genuine gap in the literature, and clinicians typically default to injectable routes when the target tissue is outside the gastrointestinal tract