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These findings integrate the compositional, biochemical, and microbial outcomes into a coherent framework, whereby FGJ exerts antidiabetic efficacy through a cascade of metabolic improvements, including lowering blood glucose, ameliorating dyslipidemia, reducing oxidative stress, and reshaping gut microbiota to enhance SCFA production

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To explore the broader impact of semaglutide on systemic pathophysiology, we performed ultra-sensitive proteomics (NULISA) on plasma samples from both groups of rats (n=12/group)

Data Availability Not applicable