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The primary mechanism documented in published literature is the induction of telomerase catalytic subunit (hTERT) expression in human somatic cells, resulting in measurable telomerase enzyme activity and telomere elongation

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doi: 10.1371/journal.pone.0153196

349 Similarly, mutations in valosin-containing protein (VCP), a multifunctional AAA-ATPase essential for extracting ubiquitinated proteins from cellular structures and directing them toward degradation, cause multisystem proteinopathies that include ALS, FTD, and inclusion body myopathy

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