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Further subgroup analysis revealed significantly higher pS- -Syn levels in patients with late-onset PD than those with early-onset disease, as well as in patients with postural instability and gait difficulties than those with tremor-predominant PD, but obviously lower in patients with cognitive deficits and olfactory loss with PD (Li X

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Less common side effects during longer trials include: darkening of lips, increase in the number of freckles, darkening of freckles, and increased libido in females