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NICE recommends that a suspected melanoma should not be excised in primary care [45], although a recent study suggests that no harm came to patients undergoing primary care excision in the rural Scottish setting [46]

8 , 10 Numerous rhabdomyomas less than 1 mm in size, so-called rhabdomyomatosis, may produce diffuse myocardial thickening without a discrete mass

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The biological mechanism is established at the level of pulse-amplitude versus basal-frequency control of somatotroph activity