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They don't

These results may suggest that GLP-1R agonists may alleviate the bloodbrain barrier breakdown induced by inflammatory factors, which is sometimes observed in depression [65]

Intracerebroventricular (ICV) infusion of native GLP-1 promotes not only a reduction in food intake and body weight, but also an increase in BAT thermogenesis induced by increased sympathetic nervous system (SNS) activity [6]

Its a shift in identity

It acts as an antifoaming agent to break up trapped bubbles and relieve abdominal pressure

Cheng CM, Mervis RF, Niu SL, Salem N Jr, Witters LA, Tseng V, Reinhardt R, Bondy CA (2003 Jul 1) Insulin-like growth factor 1 is essential for normal dendritic growth