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Dihydroorotate dehydrogenase (DHODH) is a critical enzyme that converts dihydroorotate (DHO) to orotate while reducing CoQ to CoQH 2 [84, 85]

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[2] This redox cycling property is shared by certain other agents (for example, ascorbic acid can also reduce methemoglobin, albeit less efficiently), but MB is the treatment of choice for significant methemoglobinemia because of its reliability and potency