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Phase II enzymes such as GSTP1 and GSTA1, found in several mammalian species and non-tumorous liver tissues [14] are the first step in the mercapturic acid pathway, which leads to the excretion of the xenobiotics

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It is known that the -SH group dissociates, forming the monoanion -S , which is much more reactive than the undissociated molecular form of glutathione

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(36) demonstrated that key signaling pathwaysincluding the Nrf2-Keap1 pathway, p53, and Hippo pathwaycontribute to the initiation and progression of atherosclerosis by modulating the expression and activity of ferroptosis-related proteins

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