These fats are also great for supporting your overall health
Potential Benefits in Research Weight Management Research Significant body weight reduction (up to 24% in trials) Enhanced appetite suppression through central mechanisms Improved satiety signaling Sustainable weight loss maintenance Metabolic Health Improved insulin sensitivity and glucose metabolism Enhanced lipid profile (cholesterol and triglycerides) Reduced hepatic fat accumulation Improved glycemic control in diabetic models Cardiovascular Research Blood pressure reduction in research subjects Improved cardiovascular risk markers Reduced inflammation markers (CRP, IL-6) Enhanced endothelial function Safety Profile Important: These side effects are reported from research studies and may vary by individual, dosage, and protocol
Researchers wanted to see whether a lower starting dose would reduce gastrointestinal side effects during the critical early weeks
Initially developed for type 2 diabetes, they are now recognized for their broad impact on weight regulation, inflammation, cardiovascular health, and neuroprotectiondomains central to longevity and healthy aging
doi:10.1186/s12906-017-1903-0 Salaramoli S, Mehri S, Yarmohammadi F, Hashemy SI, Hosseinzadeh H
For example, in the SELECT trial (17,600 patients with cardiovascular disease and obesity but without T2D), weekly subcutaneous Semaglutide (2.4 mg) reduced the risk of major adverse cardiovascular events (MACE heart attack, stroke, or cardiovascular death) by 20% compared to placebo (HR 0.80
