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A Multi-System Phenomenon Without a Multi-System Explanation The defining paradox of GLP-1 pharmacology is not that we know too little about its biology, but rather that we know too much in isolated fragments, and almost none of it coherently interlocks into a reproducible cross-tissue model

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Weekly self-injections remain a deterrent for many patients due to needle aversion, while refrigerated storage requirements create logistical challenges, particularly in rural and resource-limited settings

We also evaluate how other exposures and baseline health factors may affect causation, and we explain how an individual claim may fit within the broader multidistrict litigation structure