Whats happening is that the collagen in the skin is breaking down, and is not being replaced
Theranostics 7(6):15431588 Martin D, Galisteo R, Gutkind JS (2009) CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex
doi:10.1016/S0736-0266(03)00110-4 Goldstein AL, Hannappel E, Sosne G, Kleinman HK
"Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria"
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