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Results In HAP, cumulatively applied retatrutide alone (in the absence of a PDE inhibitor) elevated FOC within 10 min of incubation starting at 10 nM and reaching plateau at 100 nM retatrutide

In the REDEFINE 2 trial involving participants with type 2 diabetes, CagriSema significantly reduced HbA1c beyond what semaglutide alone achieved

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But until now, they have largely been available in the U.S

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Tolerability profile comparative data All three molecules share a typical GI adverse event profile, decreasing with progressive titration