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STEP 1 trial (Wilding et al., 2021, NEJM ): mean weight loss of 14.9% over 68 weeks, versus 2.4% on placebo

The rise of medications for weight loss has sparked interest worldwide

Future GLP-2 trials in IBD should stratify patients by disease phenotype (mucosal UC, inflammatory CD, stricturing CD) and incorporate serial cross-sectional imaging to monitor for stricture progression, given the mechanistic link between GLP-2R signaling through subepithelial myofibroblasts and intestinal fibrogenesis

Corresponding changes were observed at the phylum level (Figure S2D), where volcano plot analysis revealed marked alterations between groups, including pronounced upregulation of Pseudomonadota and Bacteroidota in the hCiPSCs-treated group, whereas Actinomycetota, Deferribacterota, and Bacillota were significantly depleted