A randomized controlled trial in 167 older adults (50 years) found two-year supplementation with vitamin B 12 (10 g/day), along with folic acid (200 g/day), vitamin B6 (10 mg/day), riboflavin (5 mg/day), and vitamin D (10 g/day), had no effect on bone mineral density (total hip, femoral neck, or lumbar spine) compared to the control group only receiving vitamin D (10 g/day ) (116)
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The compound showed an in vitro NNMT IC 50 of approximately 1.2 M and did not inhibit related methyltransferases at concentrations tested
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If oral supplements are not sufficient or absorption is compromised, periodic B12 injections may be recommended by our healthcare providers
Choline Choline is part of the vitamin B family