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However, these studies were heterogeneous and had small sample sizes

The average daily dietary iron intake is 10 to 15 mg in humans since only 1 to 2 mg is absorbed through the intestinal system

NAPQI forms adducts with mitochondrial proteins, resulting in deformations of ATP synthase, mitochondrial electron transport chain complexes, and mitochondrial DNA (mtDNA) [66,67,68]

3.3 Non coding RNA (microRNA, lncRNAs, and circRNAs) Non-coding RNAs including miRNAs, long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play crucial roles in the post-transcriptional regulation of gene expression, epigenetic control, and cellular signaling pathways in both physiological and pathological conditions

To date, only two natural products have been preliminarily implicated in necroptosis inhibition with potential relevance to ovarian protection (Supplementary Appendix 5)