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In October 2025, the FDA approved Rybelsus (oral semaglutide, developed by Novo Nordisk) to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes at high cardiovascular risk

Liver symptoms , such as liver failure, enlarged liver and spleen, elevated liver enzymes

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It takes approximately 4 to 5 weeks of consistent daily dosing to reach steady-state blood levels

If sexual side effects are persistent and significantly impacting quality of life after exhausting other strategies, discussing a switch to a different medication class or a different GLP-1 agonist with your provider is reasonable

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