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These effects cannot be dissociated from that of appetite

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Specifically, CFAs regulate Keap1 to activate Nrf2, upregulate GPX4 expression, enhance GSH-dependent lipid peroxide scavenging capacity, and preserve cell membrane integrity (4850)

ROS-induced NO inactivation can impair vascular endothelial function, contributing to various pathologies like atherosclerosis, hypertension, cardiovascular disease, and central nervous system disorders (27, 28)

We first verified that complemented cells expressed a similar level of PDS5B WT and PDS5B 17A by immunoblotting and that these proteins are properly localized in the nucleus by immunofluorescence (Supplementary Fig