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GLP-1 drugs commonly cause nausea, constipation, or an uncomfortable sense of fullness, especially early on, because they slow digestion

Daily Injectable Formulations: Liraglutide (Victoza) for diabetes starts at 0.6 mg daily for one week, then increases to 1.2 mg daily, with a possible increase to 1.8 mg if needed

The STEP trials (semaglutide) and SURMOUNT trials (tirzepatide) enrolled thousands of participants and demonstrated that GLP-1 therapy produces meaningful, sustained weight loss across diverse populations, with acceptable safety profiles when used under medical supervision

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Furthermore, the stimulation of the endothelium, results in nitric oxide increases, and oxidative stress lowers for antiatherogenic and anti-inflammatory effects

An investigation of the dual GLP-1R and neuropeptide Y2-receptor agonist, GEP44, found that this drug attenuated opioid taking and seeking at a dose that did not suppress food intake in rats 89