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It can be triggered by: Diabetes Long periods of inactivity Nutrient deficiencies Chronic stress Medications such as beta-blockers, migraine medicine or some decongestants Blood disorders like anemia Consuming large amounts of caffeine or alcohol Peripheral artery disease (PAD) When blood flow is restricted to and/or in the lower extremities due to conditions such as peripheral artery disease (the narrowing of blood vessels thats usually caused by a buildup of plaque in the arteries), circulation becomes inadequate and the extremities become cold, says Brynna Connor, MD, Healthcare Ambassador at NorthWestPharmacy.com

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