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However, in our study, deficits in glutamine and arginine were accompanied by higher levels of N-acetylspermine, thereby suggesting that polyamines could serve as a complementary sink to manage nitrogen surplus

Science 385 , 438446 (2024)

While the peptide does not increase IGF-1, caution is warranted given the theoretical relationship between growth factors and cancer progression

Senolytic therapy Elimination of senescent cells by molecules that specifically induce cell death in senescent cells to improve organismal health

Duration of effect is how long the downstream response lasts, which can be far longer than the half-life if the peptide sets off a cascade that keeps running on its own

2026 Jun 18