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I've known a lot of patients who have had detrimental outcomes from these medications. But for many who have had positive experiences with low-cost alternatives, the FDA decision is disheartening

Participants in the placebo group also reported headaches (3) and GI symptoms (1)

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even if the rats were orally administered to their maximum dose (1,600 mg/kg/d), and no adverse reactions occurred (Schauss et al., 2011

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doi: 10.1016/j.jsps.2015.03.013