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Candidates or drugs targeting the GLP-1R/GIPR, GLP-1R/GCGR, and GLP-1R/GIPR/GCGR pathways that are in Phase II/III trials or have been approved are listed below

These peptides improve insulin sensitivity, reduce HbA1c levels, and support weight loss, thereby enhancing metabolic control

Rodent GI anatomy, GH axis responsiveness, and metabolic rates differ substantially from humans

Researchers combining these compounds should start with conservative doses of each and monitor closely for unexpected effects

Sweat with a strong odor (especially at high doses)

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