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Fourteen samples with declared clomiphene were tested

The other explanation might be that mitochondrial biogenesis per se is not always assayed

Can GLP-1 treatment affect appetite

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Nonetheless, considering the clinical relevance of GLP-1 therapies and their potential impact on energy balance beyond food intake and body weight, future studies should investigate whether GLP-1 agonists influence hypothalamic neuropeptide expression or signaling cascades in MC4R-deficient models