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A recent systematic review and meta-analysis of 21 randomized, placebo-controlled trials examining the effect of B-vitamin supplementation found the supplementation decreased homocysteine concentrations and improved measures global cognitive function but had no effect on individual measures of executive function, information processing speed, or episodic memory (89)

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PepT1mediated gut uptake: In inflamed intestinal tissue, KPV is actively taken up by gut epithelial and immune cells via the PepT1 transporter, which is upregulated during inflammation

There are also food sources that are fortified with the vitamin

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