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Compounded GLP-1s on Groupon The explosive popularity of glucagon-like peptide 1 (GLP-1) agonists like semaglutide (Wegovy/Ozempic) and tirzepatide (Mounjaro/Zepbound) for weight loss has spawned a dangerous trend: their availability as unregulated, Compounded GLP-1s versions on online platforms like Groupon

In addition, gut microbes trigger the release of substances that travel to the brain and influence it

The biggest obstacle for the medications is the cost, said Pouya Shafipour, MD, a family and obesity medicine physician at Providence Saint Johns Health Center in California

If patients are looking at a $499-or-higher price tag, you might as well say it costs a million dollars a month, because theyre not going to access it. The ad features a New Yorker -styled comic strip, in which two employees at the Department of Health and Human Services (HHS) are holding a lengthy High-Priced Drug List. It would have been quicker to make a low-priced drug list, the punchline quips

Since hunger is reduced, it can be tempting to eat very little

If you experience moderate to severe gastrointestinal symptoms at any dose, extend that dose level to six or eight weeks before attempting the next increase