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Cu(II) complexes with planar aromatic ligands, such as phenanthroline derivatives in resveratrol chelates, stabilize topoisomerase I (Top1)-DNA cleavage complexes by inserting between DNA base pairs near the enzymes active site

NRF2 regulation of the osteogenic potential and self-renewal capability of MSCs could rely upon its activation of SIRT1, which is controlled at the transcriptional level by NRF2-mediated suppression of p53

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Intranasal administration may be an excellent approach for certain therapeutic effects

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