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Schenck, Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, United States This article was submitted to Structural Biology, a section of the journal Frontiers in Molecular Biosciences Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Since its isolation and characterisation in the early 1990s, it has become one of the most extensively studied peptides in regenerative biology research, with a broad research profile spanning gastrointestinal, musculoskeletal, vascular, and neurological tissue models