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Unlike stimulant-based medications, tirzepatide does not increase heart rate or metabolic stress on the thyroid gland

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Time above range was 10.3% for adults receiving combination cagrilintide and semaglutide compared with 23.7% with semaglutide alone and 28.1% with cagrilintide alone

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The only weight-loss injection with State cover is Saxenda (liraglutide), and only under the HSE Managed Access Protocol: adults with a BMI of 35+ who also have prediabetes and high cardiovascular risk, by individual HSE approval