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In a reaction, superoxide anion quickly reacts with NO radical and forms peroxynitrite (OONO ), which directly interacts with CO 2 to form other highly reactive nitroso peroxocarboxylate (ONOOCO 2 ) or peroxynitrous acid (ONOOH)

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The relative miRNA expression of each gene was normalized to the expression of U6 RNA

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Typical concentrations range from ~0.1 mM to 10 mM , depending on: Cell type (e.g., hepatocytes, neuronal cells, fibroblasts) Oxidative stress conditions (e.g., HO exposure models) Duration of exposure (acute vs