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These early studies focused on safety, tolerability, pharmacokinetics, and initial pharmacodynamic effects in healthy volunteers and patients with obesity or type 2 diabetes

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Conversely, it was found that, after adjusting for confounding factors, PPIs were not significantly associated with hazard of death with mortality survival estimates of 96.1, 96.3, and 98.0 for no medication, PPI, and H2RA, respectively (Cholin et al

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