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In an age-stratified meta-analysis of ELIXA, LEADER, SUSTAIN-6, EXSCEL, REWIND and PIONEER-6, the HR on MACE was 0.89 (95% CI 0.761.03) in those under 65 years of age and 0.86 (95% CI 0.800.92) in those aged 65 years or older ( p interaction = 0.73), 0.92 (95% CI 0.850.99) in those under 75 years and 0.75 (95% CI 0.610.92) in those 75 years or older ( p interaction = 0.07), indicating that the efficacy of GLP-1RA for MACE is consistent in older patients [8]
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In this review we focused on the ontogenesis of the regulatory pathways involved in the disposition of APAP and on the variability between pediatric, adolescent, and adult patients
Whether tumours can co-opt GSH catabolism to fuel their growth is poorly understood
Cell Biochem Biophysics
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